A seemingly subtle swap of metals—substituting a zinc ion with a cobalt ion—and a mutation ramps up the overall electric field strength at the active site of an enzyme, scientists find. The result is a predictably modified enzyme that works an astonishing 50 times faster than its unmodified analog.

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A seemingly subtle swap of metals—substituting a zinc ion with a cobalt ion—and a mutation ramps up the overall electric field strength at the active site of an enzyme, scientists find. The result is a predictably modified enzyme that works an astonishing 50 times faster than its unmodified analog.

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